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- W2355842984 abstract "Aim:To explore the influence of family history (FH),body mass index (BMI),smoking,and alcohol drinking on the risk and prognosis of gastric cardia cancer(GCC).Methods:A total of 16 605 patients with GCC and 26 053 controls were enrolled for retrospective investigation on FH,smoking,alcohol drinking,and BMI.Out of the 16 605 cases,2 000 subjects were followed-up by telephone or interviewed at home until November 2011.Survival analysis and hazard ratio(HR) estimated using Kaplan-Meier and multivariate Cox proportional hazard regression model were perfomed.Results:Positive FH was strikingly related with the high risk for GCC(P0.001,OR=2.012,95%CI =1.874~2.160); the underweight group had nearly 4-folds elevated GCC risk than the normal weight group (OR=3.864,95%CI=3.459~4.317),and it was noteworthy that overweight was a protective factor for GCC(OR=0.323,95%CI=0.293~0.357);smoking was closely related with high risk for GCC(P0.001,OR=1.979,95%CI=1.785~2.194); otherwise,the role of alcohol drinking was weak for GCC risk (P0.001,OR=0.749,95%CI=0.678~0.827).Further analysis of the relationship between FH,BMI,smoking,alcohol drinking and survival showed that only FH was related with longer survival of patients with GCC(P=0.010,RR=0.677,95%CI=0.502~0.912).Conclusion:Positive FH,smoking and underweight are related with the higher risk for GCC,while alcohol drinking is a weak risk factor for GCC;positive FH could be an independent factor for better prognosis of GCC." @default.
- W2355842984 created "2016-06-24" @default.
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- W2355842984 date "2013-01-01" @default.
- W2355842984 modified "2023-09-24" @default.
- W2355842984 title "Influence of family history,BMI,smoking,and alcohol drinking on risk and prognosis of gastric cardia cancer" @default.
- W2355842984 hasPublicationYear "2013" @default.
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