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- W2355849862 abstract "【Objective】To investigate the effects of survivin antisense oligodeoxy-nucleotid(ASODN)on 5-FU-induced apoptosis in leukemic cell line K562.【Methods】Survivin ASODN was transferred into K562 by lipofectin,and the cytotoxicity of survivin ASODN were examined by MTT assay.Morphological changes of the nucleous were observed by Hoechst33342/PI staining.【Results】The IC_(50) for K562 cells was 800 nmol/L.When K562 cells were treated with survivin ASODN at the concentration of 400,600,800 and 1 000 nmol/L the growth of cell was inhibited remarkably with dosage dependency.The inhibition effects of 5-FU+ASODN group were remarkable as compared with the simple ASODN or simple 5-FU group..Distinct morphological changes of cell apoptosis such as karyopyknosis and conglomeration were observed by Hoechst33342/PI staining.The apoptosis rate of survivin ASODN group,5-FU group and 5-FU combinated with survivin ASODN group was 54.55%,53.85% and 86.70% repectively.【Conclusion】Survivin ASODN could enhance 5-FU-induced apoptosis in leukemic cell line K562." @default.
- W2355849862 created "2016-06-24" @default.
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- W2355849862 date "2006-01-01" @default.
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- W2355849862 title "Survivin antisense oligodeoxy-nucleotid enhances 5-FUinduced apoptosis of leukemic cell line K562" @default.
- W2355849862 hasPublicationYear "2006" @default.
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