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- W2355854689 abstract "Objective: To investigate the effect of afatinib combined with cetuximab on the acquired resistance in NSCLC (non-small cell lung cancer) with EGFR (epidermal growth factor receptor) T790M mutation. Methods: The sensitivity to afatinib (10 nmol/L) in combination with cetuximab (50 μg/mL) in the primary NSCLC cells with EGFR T790M mutation was investigated by CD-DST (collagen-gel droplet embedded-culture drug sensitivity test). The proliferative and apoptotic rates of primary NSCLC cells after treatment with afatinib in combination with cetuximab were detected by cell proliferation assay (WST-1) and flow cytometry, respectively. Results: The sensitivity to combination of afatinib and cetuximab in the primary NSCLC cells with EGFR T790M mutation was higher than that to afatinib or cetuximab alone (P < 0.05). The survival rate of the primary NSCLC cells after treatment with afatinib and cetuximab was lower than that in the cells treated with afatinib or cetuximab alone (P < 0.05), whereas the apoptotic rate was reverse (P < 0.05). Conclusion: Afatinib in combination with cetuximab is effective to reverse resistance to gefitinib in primary NSCLC cells with EGFR T790M mutation. DOI:10.3781/j.issn.1000-7431.2013.07.008" @default.
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- W2355854689 date "2013-07-25" @default.
- W2355854689 modified "2023-09-27" @default.
- W2355854689 title "Overcoming acquired resistance to gefitinib in NSCLC with EGFR T790M mutation using combination of afatinib and cetuximab" @default.
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