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- W2355864555 abstract "Objective:To explore the therapeutic effect of mouse anti-human B7-1 antibody on lupus-like disease induced by Pristane in C57BL/J6 mice.Methods:Forty-five of 8-week-old female C57BL/J6 mice were divided into three groups randomly.The control group was injected with 0.5 ml 0.9%N.S.While the other two groups with 0.5 ml pristine to induce lupus-like disease.One group with pristane was intervented with mouse anti-human B7-1 antibody by caudal vein injection (the intervention group) and the other with mouse isotype IgG(the model-making group).The activation of macrophages and dendritic cells in local lymph nodes and spleens and markers on B cells in spleens were measured by FCM,respectively.Antinuclear antibody (ANA) in serum and proteinuria were detected monthly after injection.7 months after injection,all mice were killed and kidneys were sliced and stained with HE or FITC-labeled IgG to observe the evidence of glomerulonephritis histopathologically.Results:After 10 days,the intervention group and the model-making group macrophage and dendritic cells in local lymph nodes and spleens of had different levels of activation when compared with those of the control group,the activation of intervention group was significantly lower than in the model-making group (P0.05).The expressions of CD21,CD40,CD86 on spleen B cell of the intervention group increased lower than ones of the model group (P0.05).The concentration of ANA in mouse sera and protein in uria were showed the same trend.7 months later,the intervention group was showed less histopathological damages than the model-making group.Immunofluorescence intensity of immune complex(IC) in the intervention group of mouse was weaker than the model-making ones.The mice kidneys of control group mice kidneys had no significant pathological changes and IC couldn't be detected.Conclusion:Blocking B7-1/CD28 co-stimulatory signal pathway,mouse anti-human B7-1 antibody alleviate mouse lupus-like disease induced by Pristane." @default.
- W2355864555 created "2016-06-24" @default.
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- W2355864555 date "2010-01-01" @default.
- W2355864555 modified "2023-09-25" @default.
- W2355864555 title "Anti-human B7-1 antibody alleviates mouse lupus-like disease induced by pristane" @default.
- W2355864555 hasPublicationYear "2010" @default.
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