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- W2355866486 abstract "Objective:To study the hypothesis that the allogeneic bone marrow stromal cells (BMSCs), when implanted into the myocardial infarction regions, can survive the acute inflammation reaction and promote the angiogenesis. Methord:The rat acute myocardial infarction models were made by coronary artery ligation. 4 weeks later, the models were divided into 2 groups at random. In the experiment group, twice passaged BMSCs were labeled with BrdU and then implanted into the myocardium of the recipients. In the control group, the recipients received only DMEM injection. 4 weeks after implantation, the hemodynamic indexes were examined. The hearts were harvested and the infarction regions were examined to identify the angiogenesis and the phenotypes of the stem cells. Result:Viable cells labeled with BrdU can be identified in host hearts. The hemodynamic indexes were significantly improved in the cells transplantation groups. Histologic examination found most donor cells within the infarction regions expressed fibroblast-like morphologic features. Some cells incorporated into coronary capillaries outside the infarct scar. The transplantation regions had a greater capillary density than did the control regions (P 0.01). Conclusion:Our findings indicate that allogeneic BMSCs implantation can promote the angiogenesis and improve the function of heart after acute myocardial infarction. Allogeneic BMSCs can also be used as donor cells for cellular cardiomyoplasty." @default.
- W2355866486 created "2016-06-24" @default.
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- W2355866486 date "2004-01-01" @default.
- W2355866486 modified "2023-09-23" @default.
- W2355866486 title "Effects of transplantation of allogeneic bone marrow stromal cells on myocardial infarction" @default.
- W2355866486 hasPublicationYear "2004" @default.
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