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- W2355874018 abstract "Objective To observe the changes and correlation of serum levels of GH/IGF-1, IL-2, and IL-4 in hemodialysis (HD) patients for exploring its effects on immunoendocrine. Methods Thirty-five HD patients and twenty healthy control subjects were recruited for the study. Blood was drawn after an overnight fast. The serum levels of IGF-1, IL-2, and IL-4 were measured by sandwich enzyme-linked immunosorbent assay (ELISA); the serum GH level was determined by chemiluminescence assay. The multiple correlation were also analyzed between parameters including GH, IGF-1, IL-2, and IL-4. Results The levels of serum IGF-1[(252.87±82.66) ng/mL] and IL-2 [(164.35±60.86) pg/mL] markedly increased in HD group, which were significantly different from normal controls [IGF-1(60.42±14.52) ng/mL and IL-2 (114.32±53.84) pg/mL] (P0.01, 0.01). Serum GH and IL-4 levels in HD group had a little descent but there were not significantly different from those of controls (P0.05); serum GH level in HD patients was negatively correlated with IGF-1 (r=-0.38, P0.05) and IL-4 (r=-0.42, P0.05); no significant correlation was observed between GH and IL-2; serum IGF-1 levels were positively correlated with IL-2 (r=0.45, P0.01) and IL-4 (r=0.57, P0.01); and also, there was positive correlation between serum IL-2 and IL-4 (r=0.53,P0.01). Conclusion These data suggest that the imbalance of serum cytokines including IL-2 and IL-4 is associated with the altered GH/IGF-1 axis in HD patients, which probably play a role in the dysfunction of immunoendocrine." @default.
- W2355874018 created "2016-06-24" @default.
- W2355874018 creator A5068836018 @default.
- W2355874018 date "2008-01-01" @default.
- W2355874018 modified "2023-09-23" @default.
- W2355874018 title "Changes and correlation of serum GH/IGF-1,IL-2,and IL-4 levels in hemodialysis patients" @default.
- W2355874018 hasPublicationYear "2008" @default.
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