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- W2355882743 abstract "Objective To study the relationship between the expression of HIF-1αand its target genes in chronic myeloid leukemia cell line K562.Methods CoCl_2 was used as the chemical inducer to mimic hypoxia environment.K562 cells were cultured with CoCl_2 for 0,4,8 and 16 h respectively, and recorded as HOh,H4h,H8h and H16h groups.Real-Time RT-PCR and Western blot technique were applied to test the expression of HIF-1αmRNA and protein.The target genes including VEGF, MDR1/MDR3,survivin,Bcl-2,Caspase-3,Bax genes and followed by the analysis of the relationship between HIF-1αexpression and target genes controlled by HIF-1αwere estimated by Real-Time RT-PCR.Results Among HOh,H4h,H8h,and H16h groups,levels of HIF-1αmRNA remained the same(P0.05),whereas its protein increased evidently.The transcriptional activities of VEGF,MDR1/ MDR3,survivin,Bcl-2 mRNA were elevated(P0.01),whereas Caspase-3、Bax genes increased in H0h and H4h groups,but decreased in H8h and H16h groups(P0.01).Conclusion CoCl_2 chiefly enhances the expression of HIF-1αprotein in K562 cells.The genes regulated by HIF-1αare markedly changed in mRNA levels influencing greatly on survive or apoptosis of leukemia cell line K562.HIF-1αprotein may be the important factor on leukemia development." @default.
- W2355882743 created "2016-06-24" @default.
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- W2355882743 date "2010-01-01" @default.
- W2355882743 modified "2023-09-25" @default.
- W2355882743 title "The expression of Hypoxia-Inducible Factor-1α and its functional activities in leukemia cell line K562" @default.
- W2355882743 hasPublicationYear "2010" @default.
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