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- W2355891543 abstract "Objective: To study the mechanisms of shikonin induced A375 S2 cell apoptosis Method: Cytotoxicity assay by MTT, DNA fragmentation assay and Western blot analysis were carried out Result: 2 5～40 μmol·L -1 shikonin inhibited A375 S2 cell growth in a dose and time dependent manner 10 μmol·L -1 Shikonin induced apoptotic cell death in A375 S2 cells Caspase 3 inhibitor and caspase 9 inhibitor reversed shikonin induced A375 S2 cell apoptosis Up regulation of Bax and down regulation of Bcl X L experssion contributed to shikonin induced A375 S2 cell apoptosis Post mitochondrial caspase 9 dependent pathways participated in this apoptotic signal transduction pathway Conclusion: Mitochondria dependent pathways are involved in shikonin induced A375 S2 cell apoptosis" @default.
- W2355891543 created "2016-06-24" @default.
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- W2355891543 date "2004-01-01" @default.
- W2355891543 modified "2023-09-23" @default.
- W2355891543 title "Mitochondria- dependent mechanismis involved in A375-S2 cell apoptosis induced by shikonin" @default.
- W2355891543 hasPublicationYear "2004" @default.
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