Matches in SemOpenAlex for { <https://semopenalex.org/work/W2355900020> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2355900020 abstract "Objective To evaluate the human colon cancer cellular responses to a bcl 2 antisense oligonucleotide in terms of protein expression and the induction of apoptosis.Methods A human colon cancer cell line SW620 was treated with antisense oligodeoxynucleotide (bcl 2 SON) and cis platinum. Expression of bcl 2 protein was detected by flow cytometry, and the apoptotic index was detected by the TUNEL staining and flow cytometry.Results The cells exposed to bcl 2 SON exhibited a (40.3± 8.7)% reduction in bcl 2 protein expression when compared with that in the control groups (P 0.01). Combined treatment with bcl 2 SON and cis platinum could increase the apoptptic index of SW620 cells (64.7%±8.4%), in comparison to those treated with cis platinum only [(23.6± 6.3)%, P 0.01] and those treated with bcl 2 SON only [(27.5±5.1)%, P0.05].Conclusion bcl 2 SON could induce apoptosis and sensitize the cell response to chemotherapy by inhibiting the expression of bcl 2 in colon cancer cell line (SW620)." @default.
- W2355900020 created "2016-06-24" @default.
- W2355900020 creator A5058592114 @default.
- W2355900020 date "2002-01-01" @default.
- W2355900020 modified "2023-09-25" @default.
- W2355900020 title "The effect of antisense bcl-2 oligonucleotides on bcl-2 protein expression and apoptosis in human colon cancer cells" @default.
- W2355900020 hasPublicationYear "2002" @default.
- W2355900020 type Work @default.
- W2355900020 sameAs 2355900020 @default.
- W2355900020 citedByCount "0" @default.
- W2355900020 crossrefType "journal-article" @default.
- W2355900020 hasAuthorship W2355900020A5058592114 @default.
- W2355900020 hasConcept C104317684 @default.
- W2355900020 hasConcept C121608353 @default.
- W2355900020 hasConcept C129312508 @default.
- W2355900020 hasConcept C1491633281 @default.
- W2355900020 hasConcept C153911025 @default.
- W2355900020 hasConcept C185592680 @default.
- W2355900020 hasConcept C190283241 @default.
- W2355900020 hasConcept C196795494 @default.
- W2355900020 hasConcept C502942594 @default.
- W2355900020 hasConcept C526805850 @default.
- W2355900020 hasConcept C54355233 @default.
- W2355900020 hasConcept C553184892 @default.
- W2355900020 hasConcept C55493867 @default.
- W2355900020 hasConcept C81885089 @default.
- W2355900020 hasConcept C86803240 @default.
- W2355900020 hasConceptScore W2355900020C104317684 @default.
- W2355900020 hasConceptScore W2355900020C121608353 @default.
- W2355900020 hasConceptScore W2355900020C129312508 @default.
- W2355900020 hasConceptScore W2355900020C1491633281 @default.
- W2355900020 hasConceptScore W2355900020C153911025 @default.
- W2355900020 hasConceptScore W2355900020C185592680 @default.
- W2355900020 hasConceptScore W2355900020C190283241 @default.
- W2355900020 hasConceptScore W2355900020C196795494 @default.
- W2355900020 hasConceptScore W2355900020C502942594 @default.
- W2355900020 hasConceptScore W2355900020C526805850 @default.
- W2355900020 hasConceptScore W2355900020C54355233 @default.
- W2355900020 hasConceptScore W2355900020C553184892 @default.
- W2355900020 hasConceptScore W2355900020C55493867 @default.
- W2355900020 hasConceptScore W2355900020C81885089 @default.
- W2355900020 hasConceptScore W2355900020C86803240 @default.
- W2355900020 hasLocation W23559000201 @default.
- W2355900020 hasOpenAccess W2355900020 @default.
- W2355900020 hasPrimaryLocation W23559000201 @default.
- W2355900020 hasRelatedWork W1827253459 @default.
- W2355900020 hasRelatedWork W1988197509 @default.
- W2355900020 hasRelatedWork W2028048630 @default.
- W2355900020 hasRelatedWork W2052971130 @default.
- W2355900020 hasRelatedWork W2163634416 @default.
- W2355900020 hasRelatedWork W2356526771 @default.
- W2355900020 hasRelatedWork W2356920561 @default.
- W2355900020 hasRelatedWork W2377999420 @default.
- W2355900020 hasRelatedWork W2404641481 @default.
- W2355900020 hasRelatedWork W2405815479 @default.
- W2355900020 hasRelatedWork W2443234167 @default.
- W2355900020 hasRelatedWork W2460663577 @default.
- W2355900020 hasRelatedWork W2462334283 @default.
- W2355900020 hasRelatedWork W2543630978 @default.
- W2355900020 hasRelatedWork W2578718647 @default.
- W2355900020 hasRelatedWork W2589520965 @default.
- W2355900020 hasRelatedWork W3030809972 @default.
- W2355900020 hasRelatedWork W3031547892 @default.
- W2355900020 hasRelatedWork W3029825150 @default.
- W2355900020 hasRelatedWork W3031237752 @default.
- W2355900020 isParatext "false" @default.
- W2355900020 isRetracted "false" @default.
- W2355900020 magId "2355900020" @default.
- W2355900020 workType "article" @default.