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- W2355902425 abstract "The interaction between artemisinin and DNA was studied by cyclic voltammetry and UV-Vis spectroscopy in a Britton-Robinson buffer solution(pH=7.4) containing 20% ethanol.The results would be helpful to understanding the antitumor mechanism of artemisinin and its derivatives.The electrochemical results show that the reduction peak current of artemisinin at a potential of-0.672 V at sliver electrode decreased and the peak potential shifted positively with adding DNA in artemisinin solution.The comparison of the interactions of dsDNA and ssDNA with artemisinin indicates that artemisinin reacted with DNA in a mode of intercalation to form an electrochemically inactive complex.The calculation via electrochemical method shows that the ratio of DNA∶artemisinin was 1∶4 and the combination constant was 3.6×104.The determination of electrochemical parameters(α,β and Ks) in the absence and the presence of DNA also shows that an electrochemically inactive complex was formed and the reaction was controlled by a diffusion-controlled electrode process.UV-Vis spectroscopic studies further confirmed the intercalation between artemisinin and DNA.The experiments of spectroscopic titration indicated that one DNA molecule combined with four artemisinin molecules and the binding constant reached 4.0×104,which was similar to the result from electrochemical method.These results show that artemisinin might combine with the DNA of nucleus which induced the apoptosis of the cells when it entered into them." @default.
- W2355902425 created "2016-06-24" @default.
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- W2355902425 date "2007-01-01" @default.
- W2355902425 modified "2023-09-25" @default.
- W2355902425 title "Electrochemical Study on Interaction Between Artemisinin and DNA" @default.
- W2355902425 hasPublicationYear "2007" @default.
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