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- W2355906679 abstract "Objective To investigate the inhibitory effect and possible mechanism of Ganle Granule(GG)on hepatic fibrosis induced by carbon tetrachloride(CCl4)in rats.Methods Rats hepatic fibrosis was induced by CCl4 twice a week for 12 weeks.Since the 7th week,GL was given to model rats daily by intragastric administration for 6 weeks.Contents of malondialdehyde(MDA),superoxide dismutase(SOD),nitric oxide synthase(NOS)and iNOS were detected by absorption spectrometry.The serum TIMP-1 level was examined by enzyme-linked immunospecific assay(ELISA).Hepatic tissue in certain position was sampled,and TIMP-1 expression in the hepatic tissue was detected by immunohistochemical method.Moreover,TIMP-1mRNA expression in liver tissue was detected by RT-PCR technology.Results GG could significantly decrease MDA,NOS,iNOS and TIMP-1 contents,increase SOD level,and inhibit the protein and mRNA expression of TIMP-1 in hepatic tissue of hepatic fibrosis rats.Conclusion GL has an obvious anti-hepatic fibrosis action,and effectively inhibiting the expression of TIMP-1 may be one of its therapeutic mechanisms." @default.
- W2355906679 created "2016-06-24" @default.
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- W2355906679 date "2010-01-01" @default.
- W2355906679 modified "2023-09-27" @default.
- W2355906679 title "Experimental Study on Ganle Granule in Rats Counteracting Hepatic Fibrosis Induced by Carbon Tetrachloride" @default.
- W2355906679 hasPublicationYear "2010" @default.
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