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- W2355913197 abstract "Objective To explore the role of lymphocyte function-associated antigen-1(LFA-1)in the development of rheumatoid arthritis.Methods Establish mouse model of rheumatoid arthritis by induction with collagen typeⅡ.Observe the T cell proliferation and cytokine level in draining lymph nodes of mice with knock-out of LFA-1 gene.Results After treatment with collagen typeⅡ,the IFN-γ and IL-12 p40 mRNA levels in draining lymph nodes and joints of mice with knock-out of LFA-1 gene were significantly lower than those of wild mice as control,while the IL-4 mRNA level showed no significant change.After stimulation in vitro with collagen type Ⅱ,the specific proliferation and IFN-γ production of CD4+T cells derived from draining lymph nodes of mice with knock-out of LFA-1 gene were also significantly lower than those of wild mice as control.Conclusion The lack of LFA-1 gene inhibited the activation of helper T cells and its differentiation to Th1 cells,thus suppress the development of arthritis." @default.
- W2355913197 created "2016-06-24" @default.
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- W2355913197 date "2007-01-01" @default.
- W2355913197 modified "2023-09-27" @default.
- W2355913197 title "Effect of LFA-1 Gene on T Cell Activity in Draining Lymph Nodes and Joints of Mice with Collagen-Induced Rheumatoid Arthrits" @default.
- W2355913197 hasPublicationYear "2007" @default.
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