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- W2355921036 abstract "AIM To study the synergetic antibacterial effects of epicatechin gallate(ECg) and tetracycline against methicillin-resistant Staphylococcus aureus(MRSA) and methicillin-sensitive Staphylococcus aureus(MSSA) and their mechanism.METHODS Synergistic effects of ECg and tetracycline in vitro against MRSA(15 MRSA strains) and MSSA(ATCC25923) were detected by microdilution method.The inhibition of tet(K) efflux pump by ECg were determined by spectrofluorometric assays.RESULTS The MICs of ECg against MRSA and ATCC25923 were both 256 mg·L~(-1),MIC range of tetracycline against MRSA was 2 - 128 mg·L~(-1), and MIC of tetracycline against MSSA was 2 mg·L~(-1).Combined with 25 mg·L~(-1) ECg and tetracycline,synergic effect was found in five MRSA strains,additive effect was found in seven MRSA strains and the ATCC25923 strains,independent effect was found in two MRSA strains,and antagonist effect was found in one MRSA strain. The tetracycline exocytosis of tet(K) -positive strain(MRSA-2) treated by 50 mg·L~(-1) ECg and 100 mg·L~(-1) tetracycline was significantly lower than the strains treated by 100 mg·L~(-1) tetracycline alone,While the tetracycline exocytosis of tet(K)-negative strain(ATCC25923) treated by 50 mg·L~(-1) ECg and 100 mg·L~(-1) tetracycline was the same as the strains treated by 100 mg·L~(-1) tetracycline alone.CONCLUSION ECg showed synergistic or additive effects with tetracycline mainly against Staphylococcus aureu and this might be associated with the inhibition of tetracycline efflux pump." @default.
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- W2355921036 date "2009-01-01" @default.
- W2355921036 modified "2023-09-26" @default.
- W2355921036 title "Synergetic antibacterial effects of epicatechin gallate and tetracycline against Staphylococcus aureus and their mechanism" @default.
- W2355921036 hasPublicationYear "2009" @default.
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