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- W2355924369 abstract "Objective To investigate the synergetic protective effect of a nitric oxide synthase(NOS) inhibitor-L-N~(G)-nitroarginind methylester(L-NAME) combined with a calpain inhibitor-leupeptin on cochlear hair cells damaged by gentamicin(GM).Methods 20 Wistar rats(40 ears) of post-natal 3~5 days were divided equally into 5 groups: normal control,GM,L-NAME and leupeptin alone or together.The survival of cochlear hair cell in five groups was investigated by means of cochlear organotypic culture,cochlear surface preparation was stained with TRITC-Phalloidin fluorescein.Results Less cochlear hair cells were seen in GM,cell survival percentage in group treated with L-NAME or leupeptin alone was more than that in GM group(P0.01).Combination of L-NAME and leupeptin showed a higher survival percentage of cochlear hair cells than those with L-NAME(P0.01) or leupeptin(P0.01) alone.Conclusion The combination of L-NAME and leupeptin has more effective protection than alone for the cochlear hair cells from GM ototoxity." @default.
- W2355924369 created "2016-06-24" @default.
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- W2355924369 date "2006-01-01" @default.
- W2355924369 modified "2023-09-25" @default.
- W2355924369 title "Synergetic Protective Effects of L-N~G-nitroarginine methylester and Leupeptin on Damaged Cochlear Hair Cell Caused by Gentamin" @default.
- W2355924369 hasPublicationYear "2006" @default.
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