Matches in SemOpenAlex for { <https://semopenalex.org/work/W2355941621> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2355941621 abstract "In order to screen cholesterol-lowering drug from Traditional Chinese Medicine, LDLR/Lucifrase(Luc) reporter system was constructed. The LDLR/Luc reporter plasmid was transfected into HepG2 cells and the luciferase expression under the control LDLR promoter/enhancer region were obtained by the optimization of various conditions including cell density, incubated time of transfected cells and substrate volume in the assay system. As a positive control in the screening model we used paravastatin, which is known cholesterol-lowering drug, we show that the LDLR promoter activity was strongly elevated by paravastatin. These results indicated that a screening model in vitro targeting the transactivity of ldlr was established. The model was used to screen cholesterol-lowering drug from about 500 Traditional Chinese Medicine (TCM), in which Semen cassiae, Rhizoma alismatis and Dioscorea nipponica Makino exhibit positive signal, consistent with previous studies in animal model." @default.
- W2355941621 created "2016-06-24" @default.
- W2355941621 creator A5036567317 @default.
- W2355941621 date "2005-01-01" @default.
- W2355941621 modified "2023-09-25" @default.
- W2355941621 title "Construction of LDLR/Luc Reporter System and Screening of Cholesterol-lowering Drug from Traditional Chinese Medicine" @default.
- W2355941621 hasPublicationYear "2005" @default.
- W2355941621 type Work @default.
- W2355941621 sameAs 2355941621 @default.
- W2355941621 citedByCount "0" @default.
- W2355941621 crossrefType "journal-article" @default.
- W2355941621 hasAuthorship W2355941621A5036567317 @default.
- W2355941621 hasConcept C104317684 @default.
- W2355941621 hasConcept C111335760 @default.
- W2355941621 hasConcept C142724271 @default.
- W2355941621 hasConcept C150194340 @default.
- W2355941621 hasConcept C161733203 @default.
- W2355941621 hasConcept C188947578 @default.
- W2355941621 hasConcept C204787440 @default.
- W2355941621 hasConcept C2778163477 @default.
- W2355941621 hasConcept C2780035454 @default.
- W2355941621 hasConcept C2780072125 @default.
- W2355941621 hasConcept C43554185 @default.
- W2355941621 hasConcept C54009773 @default.
- W2355941621 hasConcept C54355233 @default.
- W2355941621 hasConcept C55493867 @default.
- W2355941621 hasConcept C71924100 @default.
- W2355941621 hasConcept C81885089 @default.
- W2355941621 hasConcept C86803240 @default.
- W2355941621 hasConcept C98274493 @default.
- W2355941621 hasConceptScore W2355941621C104317684 @default.
- W2355941621 hasConceptScore W2355941621C111335760 @default.
- W2355941621 hasConceptScore W2355941621C142724271 @default.
- W2355941621 hasConceptScore W2355941621C150194340 @default.
- W2355941621 hasConceptScore W2355941621C161733203 @default.
- W2355941621 hasConceptScore W2355941621C188947578 @default.
- W2355941621 hasConceptScore W2355941621C204787440 @default.
- W2355941621 hasConceptScore W2355941621C2778163477 @default.
- W2355941621 hasConceptScore W2355941621C2780035454 @default.
- W2355941621 hasConceptScore W2355941621C2780072125 @default.
- W2355941621 hasConceptScore W2355941621C43554185 @default.
- W2355941621 hasConceptScore W2355941621C54009773 @default.
- W2355941621 hasConceptScore W2355941621C54355233 @default.
- W2355941621 hasConceptScore W2355941621C55493867 @default.
- W2355941621 hasConceptScore W2355941621C71924100 @default.
- W2355941621 hasConceptScore W2355941621C81885089 @default.
- W2355941621 hasConceptScore W2355941621C86803240 @default.
- W2355941621 hasConceptScore W2355941621C98274493 @default.
- W2355941621 hasLocation W23559416211 @default.
- W2355941621 hasOpenAccess W2355941621 @default.
- W2355941621 hasPrimaryLocation W23559416211 @default.
- W2355941621 hasRelatedWork W2084327756 @default.
- W2355941621 hasRelatedWork W2230349120 @default.
- W2355941621 hasRelatedWork W2348906383 @default.
- W2355941621 hasRelatedWork W2349927035 @default.
- W2355941621 hasRelatedWork W2352405568 @default.
- W2355941621 hasRelatedWork W2352980012 @default.
- W2355941621 hasRelatedWork W2356642702 @default.
- W2355941621 hasRelatedWork W2358328660 @default.
- W2355941621 hasRelatedWork W2370368959 @default.
- W2355941621 hasRelatedWork W2372277018 @default.
- W2355941621 hasRelatedWork W2373063971 @default.
- W2355941621 hasRelatedWork W2380518829 @default.
- W2355941621 hasRelatedWork W2381427221 @default.
- W2355941621 hasRelatedWork W2385825543 @default.
- W2355941621 hasRelatedWork W2385877073 @default.
- W2355941621 hasRelatedWork W2394015970 @default.
- W2355941621 hasRelatedWork W2414193226 @default.
- W2355941621 hasRelatedWork W2418914862 @default.
- W2355941621 hasRelatedWork W2908257392 @default.
- W2355941621 hasRelatedWork W3095402078 @default.
- W2355941621 isParatext "false" @default.
- W2355941621 isRetracted "false" @default.
- W2355941621 magId "2355941621" @default.
- W2355941621 workType "article" @default.