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- W2355945934 abstract "Objective:To investigate the effect of glial cell line-derived neurotrophic factor(GDNF) on the content of nitric oxide(NO) and nitric oxide synthase(NOS) activity in spinal cord in the rat model of neuropathic pain.Methods:Adult Sprague-Dawley male rats were randomly divided into normal control group,sham operation group,spinal nerve ligation(SNL) group and SNL combined with treatment of GDNF group.Every group was divided into three sub-groups:SNL for 3d,7d and 14d(n=10 in each group).The product of NO and activity of NOS in spinal cord were examined.Results:Compared with normal control group and sham operation group,the product of NO and the activity of NOS in spinal cord of the rats in SNL group increased significantly.Compared with the rats in SNL group,there was an apparent drop in GDNF treatment group three days later in spinal cord.Conclusion:The product of NO and the activity of NOS in spinal cord may be involved in the mechanism of neuropathic pain.Intrathecal administration of GDNF could inhibit the production of NO and the activity of NOS in spinal cord." @default.
- W2355945934 created "2016-06-24" @default.
- W2355945934 creator A5056842713 @default.
- W2355945934 date "2011-01-01" @default.
- W2355945934 modified "2023-09-25" @default.
- W2355945934 title "EFFECTS OF GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR ON THE PRODUCT OF NO AND THE ACTIVITY OF NOS IN SPINAL CORD IN RATS MODEL OF NEUROPATHIC PAIN" @default.
- W2355945934 hasPublicationYear "2011" @default.
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