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- W2355946083 abstract "Objective: To observe the relative transcriptional activity of reporter gene NF-κB in HEK-293T cells and expression of TLR7,TNF-α,IL-8,IFN-βmRNA in A549 cells infected by influenza virus H3N2 and intervention of Dureping injection in different concentrations, to find the effects of influenza virus H3N2 on TLR7 signal pathyway and intervention of Dureping Injection in vitro. Methods: To detect the cell proliferation of 293T cells and A549 cells exposed to Dureping, Ribavirin and Qingkailing injections in different concentrations by MTT; The relative luciferas of NF-κB in virus-infected 293T cells was detected by Dual-Luciferase cis-Reporting Systems; The expression of TLR7,TNF-α,IL-8,IFN-βmRNA in virus-infected A549 cells were detected by RT-PCR. Results: Result of MTT showed that there was no significant difference between control cells and the cells exposed to drugs (P0.05). Compared with control cells, the relative luciferase activity of NF-κB in virus-infected cells was apparently up-regulated (P0.01). Compared with the virus-infected cells, the relative luciferase activity of NF-κB in virus-infected cells treated by three injections in different concentrations was apparently down-regulated (P0.01). And the expression of TLR7, TNF-α,IL-8,IFN-βmRNA was apparently attenuated (P0.01). Conclusion: Influenza virus H3N2 can up-regulate the TLR7 signal pathyway in vitro. Dureping injections can inhibit the inflammatory reaction induced by inl uenza virus H3N2 by down-regulating the TLR7 signal pathyway." @default.
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- W2355946083 date "2010-01-01" @default.
- W2355946083 modified "2023-09-26" @default.
- W2355946083 title "Effects of influenza virus H3N2 on TLR7 signal pathyway and intervention of Dureping injection in vitro." @default.
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