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- W2355949584 abstract "OBJECTIVE To establish a high performance liquid chromatography tandem mass spectrometry(HPLC-MS/MS) method for the determination of roxithromycin in human plasma.METHODS Plasma samples were precipitated with acetonitrile and determined by HPLC-MS/MS using clarithromycin as internal standard.The separation was carried out on a Waters ODS C18 column(2.1 mm×50 mm,3.5 μm)at 40 ℃ with a mobile phase of methanol-5 mmol·L-1 ammonium acetate(including 0.03% formic acid)(55∶45).ESI was performed in the MRM mode using target ions at m/z 837.5→679.4 for roxithromycin and m/z 748.5→590.3 for clarithromycin.RESULTS The calibration curve of roxithromycin was obtained in the range of 0.02025～13.500 mg·L-1 with good linearity(r =0.9990).The LLOQ of roxithromycin in plasma was 0.02025 mg·L-1.The absolute recovery was more than 85%,the relative recovery was 85%-115%,and the intra-and inter-day RSD were less than 15%.CONCLUSION This method has good sensitivity and precision and is suitable for pharmacokinetic studies of roxithromycin in Chinese healthy volunteer." @default.
- W2355949584 created "2016-06-24" @default.
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- W2355949584 date "2011-01-01" @default.
- W2355949584 modified "2023-09-26" @default.
- W2355949584 title "Determination of roxithromycin in human plasma by liquid chromatography tandem mass spectrometry" @default.
- W2355949584 hasPublicationYear "2011" @default.
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