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- W2355952008 abstract "Objective: To evaluate the association between methylenetetrahydrofolate reductase(MTHFR) C677 T, A1298 C genetic polymorphisms and gastric cancer in Zhejiang Han nationality population. Methods: Select 112 cases of patients with gastric cancer, choose health check-up 218 cases as controls. The genetic polymorphisms of MTHFR(C677T and A1298C) were detected by PCR-RELP method. Results: There were no significant discrepancies of the mutational allele T and variant genotype(CT+TT) frequencies in the MTHFR C677 T gene between the gastric cancer patients and the controls(34.82% vs 32.57% and 53.57% vs 52.75%, respectively, all P0.05). The frequency of mutational allele C in MTHFR A1298 C gene was significantly higher in gastric cancer patients than that in the controls(21.43% vs 12.39%, P=0.006, OR=1.929, 95%CI: 1.325~2.873). However, there were no significant discrepancies of the variant genotype frequencies(AC+CC) between the two groups(32.15% vs 36.24%, P0.05). Conclusion: The mutational allele C in MTHFR A1298 C gene may be associated with the susceptibility to gastric cancer in Zhejiang Han nationality population." @default.
- W2355952008 created "2016-06-24" @default.
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- W2355952008 date "2015-01-01" @default.
- W2355952008 modified "2023-09-23" @default.
- W2355952008 title "Relationship between the methylenetetrahydrofolate reductase C677T, A1298C genetic polymorphisms and gastric cancer" @default.
- W2355952008 hasPublicationYear "2015" @default.
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