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- W2355955064 abstract "OBJECTIVE:To evaluate the expressions and significance of HSP27、bcl-2 and p53 proteins in colorectal carcinoma. METHODS:The expressions of HSP27,bcl-2 and p53 in 72 cases of colorectal carcinoma were detected by SP immunohistochemical technique. RESULTS:The positive rates of HSP27,bcl-2 and p53 proteins were 69.44% (50/72), 54.17% (39/72) and 59.72% (43/72), respectively. The positive rate of HSP27 in the well differentiated group was 84.85%(28/33), while it was 28.57%(4/14) in the poor defferentiated group,χ~2=29.614,P=0.000. The positive rates of bcl-2 and p53 were higher in the well differentiated group than those in the poor differentiated group (χ~2=5.771,P=0.016;χ~2=4.714,P=0.030).The expression of HSP27 was related to the expression of bcl-2 ,r=0.380,P=0.001. The correlation with prognosis was analyzed by COX proportional hazards model. It showed that HSP27 was independently associated with patient survival length. CONCLUSIONS:HSP27,bcl-2 and p53 are correlated with the multidrug resistance (MDR) of colorectal carcinoma. The unitive examination of HSP27,bcl-2 and p53 may help make out a chemotherapy plan. Expression of HSP27 protein is an independent and accurate predictor of poor clinical outcome for individual colorectal carcinoma.[" @default.
- W2355955064 created "2016-06-24" @default.
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- W2355955064 date "2006-01-01" @default.
- W2355955064 modified "2023-09-22" @default.
- W2355955064 title "Expressions and significance of HSP27,bcl-2 and p53 proteins in colorectal carcinoma" @default.
- W2355955064 hasPublicationYear "2006" @default.
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