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• W2355961683 abstract "Objective To investigate the effect of spantide,neurokinin-1 receptor(NK-1R)antagonist,on the intestinal originated infection of pancreas.Methods One hundred and twenty-six adult Sprague-Dawley rats were randomly divided into control group(n=24)and experimental group(n=102);the latter included 3 subgroups:ANP/NS group(n=34),ANP/Substance P(SP)group(n=34)and ANP/spantide group(n=34).The rats in control group received laparotomy only.Sacrifices were made 8h or 16h later in control group and experimental groups after induction respectively,except for 10 rats in each ANP group for the purpose of observation.The intestine was harvested for pathologic examination.Intestinal mucosal permeability was studied by measuring the radioactivities of 99mtechnetium diethlene triamine pentacetic acid(99mTc-DTPA)content in urinary.Pancreas and the content in ileum were obtained for bacteriological culture.Results In the ANP/NS and ANP/SP group,histological damages in intestinal mucosa and pancreas were observed at 8 h after induction,which deteriorated at 16 h after induction,with a significantly higher histology scores compared with that in the control group(P0.05).As to the ANP/spantide group,the histological damages of intestine and pancreas were improved(P0.05).The mortality of ANP/spantide group was significantly lower than that of group ANP/NS and group ANP/SP(P0.05,respectively).Conclusion Spantide can protect mucous barrier,decrease the bacterial translocation and reduce the rats′ mortality." @default.
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• W2355961683 date "2007-01-01" @default.
• W2355961683 modified "2023-09-23" @default.
• W2355961683 title "Therapeutic effect of spantide on the intestinal originated infection of pancreas in acute necrotizing pancreatitis" @default.
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