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- W2355963460 abstract "Objective:To study the effects of vitamin C on the growth of human cervical carcinoma cell line,HeLa cells,and on the generation of reactive oxygen species (ROS) in the cells. Methods: HeLa cells were treated with various concentrations of vitamin C.The effect of vitamin C on HeLa cells survival and apoptosis was determined by MTT assay,light microscope and flow cytometry,and cellular ROS was measured by fluorometer. Results: After being treated with 0.25 mmol/L vitamin C for 24 h,the survival of HeLa cells did not change.However,when cells were treated with vitamin C in 0.5-4 mmol/L,the survival of cells were significantly decreased,a marked apoptosis characteristic was observed in time-and dose-dependent manner.When we measured the cellular hydrogen peroxide (H2O2) level we found that the H2O2 level in HeLa cells started to rise after being incubated with 0.5-4 mmol/L vitamin C for 15 min,and sustained increased,reached the peak point of H2O2 level at 30 min,and maintained a little time,then it began to decrease.While cells incubated with vitamin C in 0.5-4 mmol/L for 1 h to 24 h,the intracellular H2O2 level were 50% of that of the control group. Conclusion: The higher concentration of Vitamin C could induce the apoptosis on HeLa cells,derived from the solid tumors,the molecular mechanisms of which may be related to intracellular ROS level." @default.
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- W2355963460 date "2009-01-01" @default.
- W2355963460 modified "2023-09-26" @default.
- W2355963460 title "The relationship of solid tumor HeLa cells apoptosis and Vitamin C" @default.
- W2355963460 hasPublicationYear "2009" @default.
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