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- W2355965510 abstract "In order to resolute racemic naproxen with high efficiency by the immobilized Penicillium expansum TS414 lipase in organic solvent,the factors affecting the resolution of(R,S)-naproxen by lipase-catalyzed esterification reaction were investigated,including water concentration,temperature,organic solvent,enzyme concentration,structure and concentration of alcohol.And experiments were designed to optimize the conditions of esterification reaction.Under the optimal condition(isooctane as solvent,2.15 mmol/L ibuprofen,12 g/L lipase,34.3 mmol/L 1-propanol,0.05%(j) water,200 r/min,40℃ for 100 h),the conversion rate could reach 48.3%.Thus,Penicillium expansum TS414 lipase could be used as a perfect tool enzyme with high enantioselectivity and had a great potential for commercial applications in the resolution of racemic naproxen and other non-steroidal anti-inflammatory drugs of 2-aryl propionic Acids." @default.
- W2355965510 created "2016-06-24" @default.
- W2355965510 creator A5042997130 @default.
- W2355965510 date "2011-01-01" @default.
- W2355965510 modified "2023-09-23" @default.
- W2355965510 title "Enantioselective Resolution of Racemic Naproxen by a Lipase from Penicillium expansum" @default.
- W2355965510 hasPublicationYear "2011" @default.
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