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• W2355965602 abstract "[Objective]To observe the effect of Chang Ji Tai(CJT)on voltage-gated sodium channel Nav1.8 in dorsal root ganglia and nerve growth factor in the rectum of the rats with visceral hypersensitivity.[Methods]Fourty neonatal Sprague-Dawley rats were randomly divided into 4 groups:normal control group,model control group,CJT group A and CJT group B.Visceral hypersensitivity model was induced by intrarectal acetic acid irritation in the latter 3 groups.0.2ml of 0.5% acetic acid was injected into rectum through epidural catheter everyday for 3 weeks.Then CJT with concentrations of 30g/kg and 50g/kg were administered intragastrically everyday in CJT group A and B respectively while equivalent deionized water was administered intragastrically in normal control group and model control group.After 4-week treatment,rectal balloon distension was applied to evaluate visceral hypersensitivity.The pressure values inducing rat abdominal retraction and back hunch were recorded.Each value was repeated three times with a 5-minute interval and the average value was calculated.L6～S2 dorsal root ganglia and 1 cm rectum tissue were isolated for Nav1.8 mRNA and nerve growth factor measurement respectively.Real-time polymerase chain reaction(RT-PCR)and enzyme linked immunosorbent assay(ELISA)were applied to measure Nav1.8 mRNA and nerve growth factor respectively.[Results]Compared to the normal control group,the pressures inducing abdominal retraction and back hunch were significantly lower in model control group(P0.01)and CJT group A(P=0.022 and P=0.021)while the dorsal root ganglia Nav1.8 mRNA and the rectal nerve growth factor levels were significantly higher in model control group(P=0.023 and P=0.017)and CJT group A(P=0.039 and P=0.016).The pressures inducing abdominal retraction and back hunch in CJT group B were similar to those in normal control group(P=0.744 and P=0.440).There were no significant differences between CJT group B and normal control group in the levels of Nav1.8 mRNA(P=0.998)and nerve growth factor(P=0.920).[Conclusion]High dosage CJT could reduce the visceral hypersensitivity by decreasing the levels of dorsal root ganglia Nav1.8 mRNA and rectal nerve growth factor." @default.
• W2355965602 created "2016-06-24" @default.
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• W2355965602 date "2010-01-01" @default.
• W2355965602 modified "2023-09-22" @default.
• W2355965602 title "Effect of Chang Ji Tai on voltage-gated sodium channel Nav1.8 andnerve growth factor in the rats with visceral hypersensitivity" @default.
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