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- W2355974799 abstract "AIM: To investigate the effect of cycloheximide on the T cells activation by mitogen in vitro with CD69 expression as activation marker for the application of this drug clinically. METHODS:Lymphocytes were isolated from lymphoid nodes of C57BL/6 mouse. The cells were preincubated with cycloheximide(CHX), 5% serum containing CHX respectively for an hour, then further incubated with polyclonal activators (Con A or PDB). Harvesting the cells after whole incubation for 24 h, we estimated the expression rates of CD69 on T cells by flow cytometry following two-color immunofluorescent staining. RESULTS: The expression rates of CD69 on the T cells preincubated with CHX, serum containing CHX after the stimulation in response to Con A or PDB all showed significant difference with the expression rates of control group, respectively ( P 0.01). CONCLUSION: Both CHX(10 μmol/L)and 5% serum containing CHX show potently inhibitory effects on the activation of T cells in response to stimulation of Con A or PDB. Our data show that there is de novo protein synthesis for the expression of CD69 during the activation of T cells. We questioned the viewpoint that CD69 can reside within the cytoplsam and expression can occur without de novo protein synthesis." @default.
- W2355974799 created "2016-06-24" @default.
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- W2355974799 date "2002-01-01" @default.
- W2355974799 modified "2023-09-25" @default.
- W2355974799 title "Serum immunopharmacological assessment:effects of cycloheximide on the activation of T lymphocytes of mouse" @default.
- W2355974799 hasPublicationYear "2002" @default.
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