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- W2355978082 abstract "【Objective】To compare the efficacy and safety of two kinds of compound dihydroartemisinin with or without trimethoprim,i.e.Artecom(containing dihydroartemisinin,piperaquine and trimethoprim) and Artekin(containing dihydroartemisinin and piperaquine),for uncomplicated falciparum malaria,and to investigate the influence of trimethoprim in the compounds.【Methods】A two-day treatment course with a total dosage of 8 tables of Artecom and Artekin was carried out for uncomplicated falciparum malaria inpatients.Thirty-seven cases were enrolled to Artecom group and 47 to Artekin group.Average fever clearance time and average parasite clearance time were examined during 7-day hospitalization and 28-day follow-up,and then the cure rate and parasite recrudescence rate were counted.【Results】After treatment,the symptoms were released quickly in both groups.Average fever clearance time was(19.3±17.0)hours and(15.1±15.7)hours,and average parasite clearance time was(31.8±10.8)hours and(31.5±11.0)hours in Artecom group and Artekin group respectively,the difference being insignificant(P0.05).The cure rate was 100%and parasite recrudescence rate was zero in both groups,the difference being insignificant.The incidence of adverse reaction was lower in Artekin group.【Conclusion】Artecom and Artekin have similar therapeutic effect on uncomplicated falciparum malaria,but Artekin without trimethoprim has lower adverse reactions,thus it is recommended for clinical use." @default.
- W2355978082 created "2016-06-24" @default.
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- W2355978082 date "2007-01-01" @default.
- W2355978082 modified "2023-09-25" @default.
- W2355978082 title "Randomized Controlled Trial of Two Kinds of Compound Dihydroartemisinin with or Without Trimethoprim for Uncomplicated Falciparum Malaria" @default.
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