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- W2355985602 abstract "OBJECTIVE:To observe the clinical efficacy and safety of Nifedipine sustained-release tablets combined with enalapril in the treatment of elderly patients with coronary heart disease and hypertension. METHODS:92 elderly patients with coronary heart disease and hypertension were randomly divided into study group and control group. Control group was treated with Hydrochlorothiazide tablets 25 mg,po.,once a day,Nitrendipine tablets 10 mg,po.,once a day,and Isosorbide dinitrate tablets 5 mg,po.,3 times a day;study group was given Nifedipine sustained-release tablets 20 mg,po.,once a day,and Enalapril tablet 5 mg,po.,2 weeks later increasing to 10 mg,twice a day. Treatment course of 2 groups lasted for 8 weeks. Clinical efficacy,the changes of DBP and SBP before and after treatment,the incidence of ischemic events and ADR were observed in 2 groups. RESULTS:The total effective rate and the incidence of ADR in 2 groups had no statistical significance(P0.05);the levels of DBP and SBP in 2 groups before treatment also had statistical significance(P0.05). The levels of DBP and SBP in 2 groups after treatment were significantly lower than before,and those of study group were lower than those of control group;there was statistical significance(P0.05). The incidence of ischemic events in study group was significantly lower than in control group;there was statistical significance(P0.05). CONCLUSIONS:Nifedipine sustained-release tablets combined with enalapril is effective in the treatment of elderly patients with coronary heart disease and hypertension with good security." @default.
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- W2355985602 date "2014-01-01" @default.
- W2355985602 modified "2023-09-27" @default.
- W2355985602 title "Clinical Observation of Nifedipine Sustained-release Tablets Combined with Enalapril in the Treatment of Elderly Patients with Coronary Heart Disease and Hypertension" @default.
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