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- W2355985657 abstract "Objective To investigate the relationship between inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the heart of immature rabbit during the late phase of ischemic preconditioning (IP). Methods Thirty six China white rabbits (aged 2 to 3 weeks) were randomly divided into 6 groups (n=6 each group): groupⅠ, normal control; groupⅡ, ischemia/reperfusion injury (I/R); groupⅢ, I/R after IP; groupⅣ, I/R after IP adding DMSO (the solvant of NS-398); groupⅤ, I/R after IP and adding NS-398 (the COX-2 inhibitor); groupⅥ, I/R after IP and adding 1400 w (the iNOS inhibitor). The changes of LVDP and ±dp/dt max in left ventricle were monitored with Maclab/8 s system. COX-2 and iNOS in myocardium were determined. Results After 1 hour of reperfusion, the recovery rates of LVDP, +dp/dt max and -dp/dt max were significantly higher in groupⅢ and Ⅳ than in others groups (P0.01). Western immunoblotting technique showed the activity of COX-2 was markedly higher in groupⅢ than in groupsⅠ and Ⅱ, and groupsⅤ and Ⅵ(P0.05). Colorimetric assay revealed the activity of iNOS was also higher in groupⅢ than in the other groups (Ⅰ, Ⅱ, Ⅴ, Ⅵ)(P0.05). Conclusion Both iNOS and COX-2 are the factors involved in the delayed protection of IP against I/R in immature myocardium. As COX-2 is downstream of iNOS, the latter may modulate the activity of the former." @default.
- W2355985657 created "2016-06-24" @default.
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- W2355985657 date "2004-01-01" @default.
- W2355985657 modified "2023-09-24" @default.
- W2355985657 title "Effect of inducible nitric oxide synthase and cyclooxygenase-2 on delayed protection of ischemic precondtioning in immature myocardium" @default.
- W2355985657 hasPublicationYear "2004" @default.
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