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- W2355985783 abstract "AIM:To investigate the effect of sodium phenytoin(PHT)and minocycline hydrochloride(MC)compound on the healing of the defect and the expression of bone morphogenetic protein-2(BMP-2)during the periodontal bone regeneration.METHODS:A compound of PHT and MC with collagen sponge was prepared using routine method.Following surgery to create a bony window on the buccal aspect of the mandibular molar root,30 male Wistar rats were divided into two groups randomly,treated with test sponge(n=15)and control sponge(n=15)respectively.In each group,animals were sacrificed after 10(n=7)or 21(n=8)days and then the mandibles were processed for histological examination and immunohistochemical staining.The optical density(OD)of BMP-2 was analysed and compared between groups.RESULTS:At day 10,the defect area in the test group was filled with fibroblast cells and inflammatory cells while relatively less cells were seen in the control group.BMP-2 expression was seen in all these cells.The OD of BMP-2 in the test group was statistically greater than that in the control group.At day 21,large area of newly formed lamellar bone was seen in the test group while less bone in the control one.No statistical difference was found in BMP-2 expression between these two groups.CONCLUSION:The compound of PHT and MIN is able to enhance the expression of BMP-2 during the regeneration of periodontal alveolar bone in rat mandibles." @default.
- W2355985783 created "2016-06-24" @default.
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- W2355985783 date "2008-01-01" @default.
- W2355985783 modified "2023-09-25" @default.
- W2355985783 title "Effect of sodium phenytoin and minocycline hydrochloride compound on the expression of BMP-2 during the bone regeneration of periodontal fenestration defects" @default.
- W2355985783 hasPublicationYear "2008" @default.
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and%20minocycline%20hydrochloride(MC)compound%20on%20the%20healing%20of%20the%20defect%20and%20the%20expression%20of%20bone%20morphogenetic%20protein-2(BMP-2)during%20the%20periodontal%20bone%20regeneration.METHODS%3AA%20compound%20of%20PHT%20and%20MC%20with%20collagen%20sponge%20was%20prepared%20using%20routine%20method.Following%20surgery%20to%20create%20a%20bony%20window%20on%20the%20buccal%20aspect%20of%20the%20mandibular%20molar%20root%2C30%20male%20Wistar%20rats%20were%20divided%20into%20two%20groups%20randomly%2Ctreated%20with%20test%20sponge(n%3D15)and%20control%20sponge(n%3D15)respectively.In%20each%20group%2Canimals%20were%20sacrificed%20after%2010(n%3D7)or%2021(n%3D8)days%20and%20then%20the%20mandibles%20were%20processed%20for%20histological%20examination%20and%20immunohistochemical%20staining.The%20optical%20density(OD)of%20BMP-2%20was%20analysed%20and%20compared%20between%20groups.RESULTS%3AAt%20day%2010%2Cthe%20defect%20area%20in%20the%20test%20group%20was%20filled%20with%20fibroblast%20cells%20and%20inflammatory%20cells%20while%20relatively%20less%20cells%20were%20seen%20in%20the%20control%20group.BMP-2%20expression%20was%20seen%20in%20all%20these%20cells.The%20OD%20of%20BMP-2%20in%20the%20test%20group%20was%20statistically%20greater%20than%20that%20in%20the%20control%20group.At%20day%2021%2Clarge%20area%20of%20newly%20formed%20lamellar%20bone%20was%20seen%20in%20the%20test%20group%20while%20less%20bone%20in%20the%20control%20one.No%20statistical%20difference%20was%20found%20in%20BMP-2%20expression%20between%20these%20two%20groups.CONCLUSION%3AThe%20compound%20of%20PHT%20and%20MIN%20is%20able%20to%20enhance%20the%20expression%20of%20BMP-2%20during%20the%20regeneration%20of%20periodontal%20alveolar%20bone%20in%20rat%20mandibles.%22){kind=link}