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- W2355986523 abstract "Objective:To establish an ideal animal experiment model of vinorelbine-induced extravasation injury to study on effects of Fumai Paste on EGFR of skin,then discussing the curative effect and mechanism of treatment of chemotherapeutic phlebitis with external application of Fumai Paste.Methods:Forty-two rats were divided randomly into two groups with 21 rats in each group.Each rat was established experimental model.Each rat of group of Fumai Paste was treated with external application of Fumai Paste on left side;each rat of group of magnesium sulfate was treated with hydropathic compress of 50% magnesium sulfate on left side.The right side of each rat were controlled group,and were treated with hydropathic compress of normal saline.Three rats were selected randomly from each group in 1day,4days,7days,11 days,14days and 18 days,and the skin and subcutaneous tissue of extravasation injury of each rat was cut off.All specimens were fixed in formalin,were dehydrated,embedded in paraffin and serially cut.All specimens were observed expressions of EGFR under the electron microscope by immunohistochemical assay and image analysis method.Results:The positive expression of EGFR was major in epidermic cells,dermal fibroblast,hair follicle cells,vascular endothelial cell,macrophage,cell membrane and endochylema of neutrophile granulocyte.Fumai Paste could stimulate the positive expression of EGFR of skin of animal experiment model of vinorelbine-induced extravasation injury more earlier and more strong than 50% magnesium sulfate and normal saline(P0.05).Conclusion:Fumai Paste can remarkable promote the increase of EGFR of skin of animal experiment model of vinorelbine-induced extravasation injury.Then with the generation of granulation tissue and squamous epithelium,Fumai Paste can accelerate the healing of the damaged skin.So chemotherapeutic phlebitis can be prevented and treated by external application of Fumai Paste." @default.
- W2355986523 created "2016-06-24" @default.
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- W2355986523 date "2014-01-01" @default.
- W2355986523 modified "2023-09-28" @default.
- W2355986523 title "Effects of Fumai Paste on EGFR of Skin in Vinorelbine-induced Extravasation Injury Model Rats" @default.
- W2355986523 hasPublicationYear "2014" @default.
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