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- W2355987855 abstract "Objective: To investigate the method of improving the successful rate of the establishment of abdominal aortic aneurysm(AAA)rat model. Methods:Wistar rats were divided into control group and improving method group,and AAA models were made with traditional and improved method respectively. The injury of artery wall,infiltration of inflammatory cells,and mRNA expression of endogenous elastic enzyme were observed by using special staining of elastic fibers and collagen,immunohistochemical staining,and in situ hybridization.The 2 methods were compared. Results:In improving method group the successful rate of animal model were 90%.The positive cells of CD68 immunohistochemical staining were much more than that in control group.And the positive expression level of MMP-2 mRNA were also higher. Conclusion:To make full use of microsurgery technique in establishment of AAA animal model can improve the successful rate. And it is also important to keep certain concentration of perfusate." @default.
- W2355987855 created "2016-06-24" @default.
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- W2355987855 date "2004-01-01" @default.
- W2355987855 modified "2023-09-26" @default.
- W2355987855 title "Application of microsurgery technique in establishment of animal model of abdominal aortic aneurysm" @default.
- W2355987855 hasPublicationYear "2004" @default.
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