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- W2355988634 abstract "Objective To investigate the single nucleotide polymorphisms(SNPs)of MMPs and TIMPs gene in Chinese Han population of Chengdu.Methods The genotypes and allele frequencies of six MMPs(MMP1-1607 1G/2G、MMP2-1306C/T、MMP2-735C/T、MMP3-1612 5A/6A、MMP9-1562 C/T、MMP21 572 C/T),and two TIMPs(TIMP2 303C/T、and TIMP3-1296 C/T)were analyzed in 132 healthy Chinese Han people from Chengdu,using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP),and then to compare the distributions of alleleic frequencies and the haplotypes of MMPs and TIMPs to those of the Han of northern china,Japanese and European populations.Results The allelic frequencies of allele,genotype and haplotype distributions of these SNPs were summarized in our study.Except for the MMP21 572 C/T,the other allele,genotype and haplotype frequencies of MMPs and TIMPs in the Chinese Han of Chengdu were significantly different from those among the Han of northern China,Japanese and European populations.Conclusion The allelice frequencyies of distribution of MMPs and TIMPs genes in the Han ethnic of Chengdu presentsed their own characteristics,and the shows geographic differences." @default.
- W2355988634 created "2016-06-24" @default.
- W2355988634 creator A5074898112 @default.
- W2355988634 date "2011-01-01" @default.
- W2355988634 modified "2023-09-28" @default.
- W2355988634 title "Genetic polymorphism and haplotype of MMPs and TIMPs Genes in Chinese Han population of Chengdu" @default.
- W2355988634 hasPublicationYear "2011" @default.
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