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- W2355990362 abstract "Objective To investigate the effect of curcumin on the sensitivity of human leukemia cell line HL-60 to adriamycin.Methods Cytotoxicity was determined by the colorimetric MTT viability/proliferation assay.Apoptosis was assessed by flow cytometry.The mRNA levels of survivin and XIAP were measured by RT-PCR.The protein levels of survivin and XIAP were measured by Western blot.Results Simultaneous administration of curcumin(2.00～16.00 μmol·L-1) and adriamycin(0.08～0.64 μmol·L-1) resulted in synergistic cytotoxicity and apoptosis for HL-60 cells.Meanwhile,cell apoptosis was increased and the mRNA and protein levels of Survivin and XIAP were significantly down-regulated.Conclusion Curcumin can sensitize human leukemia cell line HL-60 to adriamycin-mediated apoptosis.Down-regulation of Survivin and XIAP gene expression and promoting cell apoptosis are main mechanisms." @default.
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- W2355990362 date "2009-01-01" @default.
- W2355990362 modified "2023-09-23" @default.
- W2355990362 title "Effect of Curcumin on the Sensitivity of Human Leukemia Cell Line HL-60 to Adriamycin" @default.
- W2355990362 hasPublicationYear "2009" @default.
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