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- W2355991464 abstract "The implants were prepared by incorporating doxorubicin hydrochloride into poly(lactide-co-glycolide)(PLGA) matrix.The drug release rate and content of implants were determined by HPLC,and the weight loss of PLGA was also tested.The result showed that in vitro degradation curve of PLGA appeared to be like 'S'.The degradation rate of PLGA was enhanced followed by an initial lag time,and the weight loss of PLGA was 80% for 5 weeks.The implants provided zero-order drug release at a rate of 3.26% per day for 25 days(r=0.9880).The cumulative release rate of the implant was more than 90% at 35 days.The drug release from the implants has sustained for 1 month.The drug release rate of the implant depends predominantly on the degradation rate of PLGA.This release is well controlled by regulating the degradation rate of PLGA matrix." @default.
- W2355991464 created "2016-06-24" @default.
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- W2355991464 date "2011-01-01" @default.
- W2355991464 modified "2023-09-22" @default.
- W2355991464 title "Study on Release of Doxorubicin Hydrochloride from Sustained-Release Implant and Degradation of Poly(lactide-co-glycolide) in Vitro" @default.
- W2355991464 hasPublicationYear "2011" @default.
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