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- W2355996599 abstract "Objective To investigate the effect of ischemia and reperfusion of hindlimb in rats on ultrastructurechanges of motor neuron of anterior horn in lumbar enlargement of spinal cord and their internal relation. MethodsThe model of temporary occlusion of the common iliac, internal iliac, external iliac and femoral artery was set up. Theultrastructure changes of motor neurons of anterior hom in lumber enlargement of spinal cord at various intervals wasobserved under transmission electron microscope. Results Normal neuron ultrastructure was found in the controlgroup. Dark neurons were observed in all 3 groups (6, 8 and 12 hours intervals). The definitive neurons necrosis wasfound at 8 hours ischemia. Severe neurons necrosis and damage of blood-brain barrier were developed at 12 hoursischemia. In each group, the longer the reperfusion period (shorter than 60 hours), the more severe the damage of theneurons. Conclusion The ischemia and reperfusion injury to the peripheral nerve in hindlimb in rats can give rise tothe ultrastructure changes of motor neuron of anterior horn in lumbar enlargement of spinal cord, resulting in darkneuron and neuron necrosis. As the duration of ischemia and reperfusion prolongs, the damage of neuron becomes moresevere." @default.
- W2355996599 created "2016-06-24" @default.
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- W2355996599 date "2004-01-01" @default.
- W2355996599 modified "2023-09-26" @default.
- W2355996599 title "The ultrastructure changes of motor neuron of anterior horn in lumbar enlargement of spinal cord after hindlimb ischemia and reperfusion in rats" @default.
- W2355996599 hasPublicationYear "2004" @default.
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