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- W2356000247 abstract "Objective To evaluate the effect of combined anesthesia using Fentanyl、Suxamethonium chloride and Pentobarbotal sodium in pigs of acute myocardial infarction(AMI) and establish the optimal anesthesia in large animal experiments.Methods 28 young farm pigs were divided into operated(n=22) group and sham-operated(n=6) group.The left anterior descending(LAD) coronary artery distal to the second or third diagonal branch was ligated.Sham-operated animals underwent a similar procedure except that LAD was not lighted.Ketamine(10 mg/kg) and Atropine(0.5 mg/mL pig) were injected into operated pigs through IM to perform anesthetic inducement.Pentobarbotal sodium(20 mg/kg) and Fentanyl(0.008 mg/kg) were slowly injected by intravenous anesthesia before operation.The muscle of operated animals was relaxed by Suxamethonium chloride(5 mg/kg) during operation.The operated pigs were intubated,and mechanically ventilated.Results The pigs with Combined anesthesia had advantages as follow: stable circulatory function,quicker awakeness,and better quality of recovery.The mortality from AMI pigs was great reducing(20%).After LAD ligated,S-T elevation to single-phase curve appeared in the operated animals.The infarcted areas were offwhite by the TTC stain method.Light microscopy examination showed symmetrical fibrous connective tissue proliferation in the infracted area.Conclusion The method of combined anesthetic can be applied in large animal experiments satisfactorily." @default.
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- W2356000247 date "2007-01-01" @default.
- W2356000247 modified "2023-09-24" @default.
- W2356000247 title "Application of Combined Anesthesia with Fentanyl,Suxamethonium and Pentobarbotal in Pigs Model of Acute Myocardial Infarction" @default.
- W2356000247 hasPublicationYear "2007" @default.
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