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- W2356012591 abstract "Background The recent studies have shown that the application of secondary prevention medication and patients' drug therapy compliance are poor.Objective To evaluate the antithrombotic agent compliance of IS patients' and the application of drugs controlling risk factors and analyze the reasons for patients' poor medication compliance and discontinuation of medication.Methods The patients with acute myocardial infarction(AMI) or transient ischemic attack(TIA) hospitalized in this hospital from August 2011 to June 2012 were enrolled in this study.The status of medication and reasons for discontinuation of medication were recorded within 12 months after discharge.Medication days according doctors' advice equal to or more than 80% of follow-up days were considered as good compliance.Medication during follow-up consistent to that at discharge considered as good persistence.Results A total of 393 patients were enrolled,31 were excluded;362 entered into follow-up study,including 40 losing follow-up due to varying reasons within 12 months,18 excluded due to dying during follow-up,304(77.4%) completed the follow-up study at last.In the 304 patients,217 had good compliance to antithrombotic agents,87 had poor.The relevant factors influencing medication compliance were educational level(χ2= 5.523,P = 0.019),reimbursement methods(χ2= 12.233,P = 0.002) and stroke subtype(χ2= 16.562,P = 0.000).There was significant difference in medication compliance of aspirin at different time points after discharge(P 0.05).The compliance was lower in months 6,12 than in month 1 after discharge(P 0.05).There was no difference in clopidogrel,doublet and warfarin compliance at different follow-up time points(P 0.05).There was difference in medication persistence of 4 antithrombotic drugs in months 12 after discharge(χ2= 20.025,P = 0.000),the persistence of aspirin was higher than that of clopidogrel and doublet(=18.484,P =0.000,χ2= 6.660,P = 0.010).The good compliance rate of patients combined with hypertension,diabetes and hyperlipemia in months 12 were 66.5%(157 /236),77.1%(84 /109),39.3%(92 /234),respectively.The main reason for poor antithrombotic drug compliance was poorly understanding the course of treatment 〔54.0%(47 /187) 〕,reasons for antihypertensive,hypoglycemic drug compliance was drug discontinuance due to normal examination indicators 〔26.6%(21/79),48.0(12/25) 〕,reasons for lipid-lowering drug compliance was not knowing course of treatment 〔53.5%(76/143) 〕.Conclusion Secondary preventive medication adherence is generally low within 12 months after discharge,aspirin medication compliance is higher than that of clopidogrel and doublet.The main reasons for poor compliance are poorly understanding course of treatment,discontinuity due to improved symptoms and to normal examination indicators.Educational level,reimbursement methods,stroke subtype are factors influencing antithrombotic drug compliance." @default.
- W2356012591 created "2016-06-24" @default.
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- W2356012591 date "2014-01-01" @default.
- W2356012591 modified "2023-09-23" @default.
- W2356012591 title "Secondary Preventive Medication Adherence in Patients with Ischemic Stroke after Discharge" @default.
- W2356012591 hasPublicationYear "2014" @default.
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