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- W2356038560 abstract "To investigate the effect of PrP105-132 on secretion of interleukin 8(IL-8)from microglial cells in vitro and its possible pathway,rat neuroglial cells were cultured in vitro,and these microglial cells were treated with PrP105-132.IL-8level in supernatant fluid was detected using enzyme-linked immunosorbent assay(ELISA).The expression of nuclear factor kappa-light-chain-enhancer of activated B cells(NF-κB)was evaluated using reverse transcription polymerase chain reaction(RTPCR)and western blot.The microglial cells were activated by treatment with PrP peptides.Cell bodies were augmented and presented round,rod,and amoeba-like shapes.The protuberances were shortened and finally disappeared.IL-8level increased in supernatant fluid.However,the mRNA and protein expression of NF-κB decreased after these cells were treated with MG132,a specific inhibitor of NF-κB.PrP-treated microglial cells secreted IL-8.The secretion of IL-8is mainly dependent on the NF-κB pathway." @default.
- W2356038560 created "2016-06-24" @default.
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- W2356038560 date "2015-01-01" @default.
- W2356038560 modified "2023-09-26" @default.
- W2356038560 title "Effect of PrP105-132 on secretion of IL-8 from microglial cells in vitro" @default.
- W2356038560 hasPublicationYear "2015" @default.
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