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- W2356040575 abstract "Objective To investigate the changes of endogenous hypoxia inducible factor-1α(HIF-1α) expression following lung ischemia/reperfusion(I/R) in rats.Methods A total of 150 male Wistar rats were divided into sham operation group(S),Soluble tumor necrosis receptor-Fc group(TF) and I/R group,each group was subdivided into 5 subgroups according to reperfusion time of 0,1,2,4 and 8h,respectively.The left lung was taken from each group.Pathological changes and HIF-1αexpression were detected by using histopathology and tissuemicroarry,immunohisto-chemistry,image analysis techniques.Results The expression levels of HIF-1αwere much higher in I/R than those in S and TF(P0.05).The increase of HIF-1αwas observed in nucleus.Conclusion HIF-1αmay play an important role in the lung injury after ischemia/ reperfusion." @default.
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- W2356040575 date "2009-01-01" @default.
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- W2356040575 title "Effect of HIF-1α in lung ischemia/reperfusion injury in rats" @default.
- W2356040575 hasPublicationYear "2009" @default.
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