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- W2356060139 abstract "Objective To investigate the mRNA expressions and enzymatic activities for both matrix metalloproteinase-2(MMP-2)and tissue inhibitor of metalloproteinase-2(TIMP-2)in human gliomas and their significances. Methods The samples from 26 cases of glioma were divided into four groups according to the WHO classification, normal brain samples served as the control. The mRNA expressions for both MMP-2 and TIMP-2 were determined using reverse transcriptase-polymerase chain reaction(RT-PCR)and the enzymatic activities of MMP-2 and TIMP-2 were detected by gelatin zymography in the samples. Results In gelatin zymography, MMP-2 revealed two bands, which were localized at 62 000 (activated form) and 72 000 (latent zymogen form) of MMP-2, respectively. The latent zymogen form(72 000) of MMP-2 was not different among the four grades of gliomas. The mRNA expression level and the enzymatic activity of MMP-2 were significantly elevated with the malignant grade of the gliomas, while the mRNA expression level and the activity of TIMP-2 were markedly reduced with increasing the malignant grade of the gliomas. Conclusion The gene transcription and the enzymatic activities for both MMP-2 and TIMP-2 have changed in human gliomas with different grades of malignancy, which play an important role in the facilitation of glioma invasion." @default.
- W2356060139 created "2016-06-24" @default.
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- W2356060139 date "2005-01-01" @default.
- W2356060139 modified "2023-09-25" @default.
- W2356060139 title "Changes of mRNA expressions and enzymatic activities for both MMP-2 and TIMP-2 in human gliomas and their significances" @default.
- W2356060139 hasPublicationYear "2005" @default.
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