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- W2356065263 abstract "OBJECTIVE To explore the protective effect of HSP72 on the acute injury of cardiomyocyte induced by oxidative stress. METHODS Cardiomyocytes of neonatal rats treated with heat shock (42 degrees C, 30 min, recovery for 6 h) to induce the expression of HSP72 and HSP72 antisense oligonucleotide was transformed to block the expression of HSP72. 0.5 mmol/L (final concentration) H2O2 was added into the culture medium to mimic oxidative stress, and to induce the acute injury of neonatal cardiomyocytes. The release of LDH and the total protein synthesis were applied to evaluate the injury of cardiomyocyte of neonatal rats. RESULTS Oxidative stress could significantly increase the release of LDH, and inhibit the total protein synthesis. By inducing the expression of HSPs, heat shock pretreatment significantly reduced the release of LDH and relieved the oxidative stress-mediated inhibition of total protein synthesis. Moreover, HSP7-2 anti-sense oligonucleotide could remarkably block the protective effect of heat shock pretreatment on the cellular injuries induced by H2O2. CONCLUSION HSP72 plays a most important role in the acute injury of cardiomyocyte mediated by oxidative stress." @default.
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- W2356065263 date "2006-04-01" @default.
- W2356065263 modified "2023-09-24" @default.
- W2356065263 title "Effect of HSP72 on acute injury of neonatal cardiomyocytes induced by oxidative stress" @default.
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