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- W2356090155 abstract "Objective To evaluate and compare the effects of brucine and its liposome on inhibiting transplanted tumor growth and prolonging their survival time in mice with transplanted tumor cells. Me- thods ICR Mice of tumor model was made by inoculated with tumor cells (S_ 180 , EAC, and Heps). The antitumor activity of brucine and its liposome was evaluated by tumor inhibitory ratio for S_ 180 and Heps and life prolonging rate for EAC and Heps of mice with transplanted tumor. Results Brucine and its liposome had significant inhibiting effect on transplanted tumor growth in mice. Inhibitory rates of brucine on Heps were 35.05% [1.61 mg/(kg·d)], 43.70% [3.23 mg/(kg·d)], and 46.09% [6.46 mg/(kg·d)], while of its liposome on Heps was 45.41% [1.61 mg/(kg·d)] and 58.19% [3.23 mg/(kg·d)], respectively. The inhibitory rate of brucine on S_ 180 was 37.59% [1.61 mg/(kg·d)], 36.13% [3.23 mg/(kg·d)], and 38.87% [6.46 mg/(kg·d)], while of its liposome on S_ 180 was 53.00% [1.61 mg/(kg·d)] and 48.37% [3.23 mg/(kg·d)], respectively. However, both of them had no distinct effect on prolonging the life of mice with transplanted tumor (EAC and Heps). Conclusion Brucine and its liposome could inhibit the growth of transplanted solid tumor and the inhibitory effect of its liposome is much stronger than that of brucine." @default.
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- W2356090155 date "2006-01-01" @default.
- W2356090155 modified "2023-09-25" @default.
- W2356090155 title "Comparison of antitumor effect between brucine and its liposome in mice transplanted with tumor in vivo" @default.
- W2356090155 hasPublicationYear "2006" @default.
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