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- W2356092021 abstract "OBJECTIVE: To seek for the farnesoid X receptor (FXR) inhibitors from the TCM database using chemoinformatics.METHODS: Three-dimensional structure active fraction of FXR-fexaramine compound (PDB code: 1OSH) was analyzed using Cerius2 4.10 software package developed by Accerlrys company.Ligandfit module was applied for molecular docking.RESULTS: 10 compounds which were predicted to have good interactions with FXR were screened using docking score of original inhibitor (fexaramine) and the receptor as threshold value.CONCLUSION: The study could be helpful for development of new lipid-lowering drug and further study of mechanism of FXR and pharmaceutical molecular." @default.
- W2356092021 created "2016-06-24" @default.
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- W2356092021 date "2010-01-01" @default.
- W2356092021 modified "2023-09-23" @default.
- W2356092021 title "Computer Virtual Screening of Farnesoid X Receptor Inhibitors Based on the TCM Database" @default.
- W2356092021 hasPublicationYear "2010" @default.
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