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- W2356100449 abstract "Purpose To explore the relationship between the XPF gene RS744154 polymorphism and risk of gastric carcinoma(GAC) and its clinicopathologic features among Guangxi area.Methods This study,including GACs(n=99) and control group(n=284),was carried out to analyze XPF RS744154 polymorphism using TaqMan-PCR technique.Then association analyses was performed between these polymorphism sites and the clinicopathologic features of GAC.Results We found the distribution of three XPF genotypes(namely XPF-GG,-GC,and-CC) were found in GAC was significantly different from the controls(P0.05).Compared with GG genotype,CC can increase the risk of GAC(corresponding OR was 2.60 for XPF-CC).In the stratified analysis,we also observed that males、The Han nationality or elders having risk genotypes(OR1,also called XPF-GC/CC) which will increase the risk of GAC(OR was 2.25、1.95 and 3.00,respectively) compared to those without risk genotypes.The frequencies of the XPF-GG,GC/CC genotypes were 43.75%,71.64% in patients with tumor diameter(≤ 5 cm),and 56.25%、28.36% in patients with tumor diameter(5 cm),respectively.The difference was statistical significance(χ2=7.198,P=0.007,OR=3.69).No relationship was found between XPF gene polymorphisms and tumor sites,pathologic grade,Lauren classification,lymph nodemetastasis,TNM stage.The distribution of HP infection among three XPF genotypes(namely XPF-GG,-GC,and-CC) was not significantly difference in GAC(P0.05).Conclusion These results suggest that XPF RS744154 polymorphism may associate with the risk of gastric adenocarcinoma among Guangxi population,especially among males the Han nationality and elders.The distribution of HP infection in the paracancerous mucosa and the XPF gene RS744154 polymorphism is not significantly difference.Furthermore,XPF gene polymorphism also may not correlation with the clinico-pathologic feature." @default.
- W2356100449 created "2016-06-24" @default.
- W2356100449 creator A5074400802 @default.
- W2356100449 date "2011-01-01" @default.
- W2356100449 modified "2023-09-27" @default.
- W2356100449 title "Relationship between the XPF gene RS744154 polymorphism and risk of gastric carcinoma and its clinicopathololgic features among guangxi area" @default.
- W2356100449 hasPublicationYear "2011" @default.
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