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- W2356100473 abstract "Objective:To observe the effect of dioscornin on expression of tumor necrosis factor-α(TNF-α)of experiment atherosclerosis(AS)rats and investigate whether its anti-inflammatory action on AS or not.Methods:60 male SD rats were randomly divided into five groups:sham operation group,model group,aspirin group,dioscornin low and high dosage groups with 12 in each group.After 7d,the balloon-injured carotid artery angioplasty was performed in the rats of all groups except sham operation group.3 months later,all rats were killed for serum triglyceride(TG),cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),levels of TNF-αand arteriae carotis communis pathology determination by Immunohistochemistry and Westen-blot methods.Results:Compared with the model group and the aspirin group,the levels of serum TG,TC and LDL-C in dioscornin high dosage group were significantly decreased.However,there was no significant difference between dioscornin low dosage group and model groups.The levels of serum HDL-C were no significantly differences among all groups.In the impaired side,W/L ratio of carotid artery in the model group was thicker obviously than that in sham operation group.Meanwhile there was plaque formed locally.The W/L ratios of carotid artery in dioscornin low and high dosage group were thinner than that in model group.That of dioscornin high dosage group was thinner than aspirin group.The W/L ratios of carotid artery in dioscornin low dosage group and model group were no significant difference.Immunohistochemistry staining and Western blot method showed that the levels of TNF-αin dioscornin low and high dosage groups were significantly decreased compared with the model group.That of dioscornin high dosage was significantly lower than that of aspirin group.That in dioscornin low dosage group and aspirin group were no significant difference.Conclusion:Dioscornin can reduce the levels of TNF-αin the experiment atherosclerosis rats and take the effect of anti-inflammatory to treat artherosclerosis." @default.
- W2356100473 created "2016-06-24" @default.
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- W2356100473 date "2009-01-01" @default.
- W2356100473 modified "2023-09-28" @default.
- W2356100473 title "The Effect of Dioscornin on Expression of TNF-α in the Experiment Atherosclerosis Rats" @default.
- W2356100473 hasPublicationYear "2009" @default.
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