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- W2356109007 abstract "Objective:To study the cooperative effect of Arsenic trioxide(As2O3)combined with 10-Hydroxycamptothecine(HCPT)on hepatocellular carcinoma cell line SMMC-7721.Methods:The human hepatocellular carcinoma cell line SMMC-7721 were cultured with As2O3 combined with /without HCPT in certain concentration gradient.The MTT was used to observed dynamically the effect of the cell growth inhibiting,and the character of the two drugs interaction was estimated by coeffient of drug in interaction(CDI).Results:The combination of 0.5μg/ml As2O3 and 0.5μg/ml HCPT effects much more than either of them alone to inhibit growth of SMMC-7721(P0.01),furthermore,the combination of two drugs had a synergistic effect.Conclusion:The combination of As2O3 and HCPT increase the effect against the cancer and reduce the dosage and toxicity of each." @default.
- W2356109007 created "2016-06-24" @default.
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- W2356109007 date "2007-01-01" @default.
- W2356109007 modified "2023-09-24" @default.
- W2356109007 title "Study on synergetic anti-cancer effects with arsenic trioxide and 10-hydroxycamptothecine in hepatocellular carcinoma cell" @default.
- W2356109007 hasPublicationYear "2007" @default.
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