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- W2356116099 abstract "Objective: To observe the effect of scutellarin(Scu) on expression of several inflammatory factors in the brains of rats with dementia and to reveal the possible therapeutic mechanism on dementia.Method: Wistar rats were randomly divided into 5 groups,ie,normal,sham operation,learning and memory deficit model,Scu treatment and piracetam treatment groups.The rat dementia model was produced by bilateral ventricle injection with β-amyloid peptide(Aβ25-35) and abdominal cavity injection with D-galactose.The rats in Scu or piracetam group were treated with 28 mg.kg-1 and 365 mg.kg-1 of 0.5% Scu or 64 g.L-1 piracetam by intragastric gavage(ig) for 20 days after modeling.NF-κB p65 at mRNA levels were detected by real-time PCR,and the expressions of interleukin-1β(IL-1β),interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) were observed by immunohistochemistry method in the brain of rats.Result: As compared to normal or sham operation groups,NFκB p65 mRNA expression in the model group was up-regulated by 27% and 31%,the expressions of IL-1β,IL-6 and TNF-α were increased from 1.3 ± 0.48,1.6 ± 0.52,1.6 ± 0.69 and 1.5 ± 0.53,1.6 ± 0.70,2.0 ± 0.67 to 2.9 ± 0.74,3.2 ± 0.79,3.0 ± 0.82(P 0.05).After treatment by Scu,NF-κB p65 mRNA expression were down-regulated by 20%(P 0.05) and scores of positive cells of IL-1β,IL-6 and TNF-α were respectively decreased by 2.1 ± 0.67,2.3 ± 0.70,2.2 ± 0.53(P 0.05) in brain tissues as compared to learning and memory deficit group.Conclusion: By preventing activation of NF-κB p65 and inhibiting releasing of mediators of inflammation,Scu may be able to improve the ability of learning and memory of the rats with dementia and to educe neuroprotective effects." @default.
- W2356116099 created "2016-06-24" @default.
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- W2356116099 date "2013-01-01" @default.
- W2356116099 modified "2023-09-25" @default.
- W2356116099 title "Intervention of Scutellarin on Neuro-inflammatory Reaction in the Brains of Rats with Dementia" @default.
- W2356116099 hasPublicationYear "2013" @default.
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