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- W2356118464 abstract "Objective To explore clinical application value of thrombus precursor protein(TPP) in patients with thrombosis and anticoagulant treatment after the heart valve replacement.Methods Case group consisted of 30 heart valve replacement patients and control group consisted of 20 healthy volunteers.Five platelet(PLT) parameters,TPP,D-dimer,prothrombin time(PT),international normalized ratio (INR) and fibrinogen (Fib) were measured before surgery and 1,3,7 days after surgery in patients of case group and in volunteers of control group.All data were analyzed using statistical methods.Results PT,INR,D-dimer,TPP levels were significantly higher in patients with heart valve disease preoperatively than in volunteers and five platelet parameters showed no significant difference between the 2 groups.In case group,PLT,PT,INR,D-dimer were significantly higher 7 days after operation than 1 day post-operation.TPP level was significantly higher 7 days after operation than 3 days post-operation.INR 95% of confidence limit in 10 patients who had no thrombosis or bleeding was 1.80 — 2.80,which was appropriate INR in patients after operation.Conclusions The patients have obvious tendency towards thrombosis 7 days after heart valve replacement.It is recommended to detect four parameters including TPP, D-dimer,INR and PLT in conjunction with changes in various parameters after operation as indicator system for clinical anticoagulant treatment." @default.
- W2356118464 created "2016-06-24" @default.
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- W2356118464 date "2010-01-01" @default.
- W2356118464 modified "2023-09-23" @default.
- W2356118464 title "Application value of thrombus precursor protein in thrombosis and anticoagulation monitoring after heart valve replacement" @default.
- W2356118464 hasPublicationYear "2010" @default.
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