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- W2356137283 abstract "Objective To study the relationship between polymorphism of cytochrome P4502E1(CYP2E1) gene and susceptibility to gastric cardia cancer (GCC).Methods A case control study was used.The frequency of CYP2E1 genotype between patients with GCC and controls were detected by polymerase chain reaction restriction fragment polymorphism (PCR RFLP).Results The distribution of three genotypes of CYP2E1 in GCC and controls was significantly different ( χ 2= 16.04 , P 0.01 ).The odds ratio were 2.37 (95% CI : 1.52 ～ 3.70 ).The frequency of CYP2E1 (c1/c1) genotype in GCC cases and controls was 60.4% and 40.1% respectively.Subjects who had CYP2E1(c1/c1) genotype and having smoking habit were at a significantly higher risk of developing GCC ( OR = 4.68 ,95% CI : 2.19 ～ 10.04 ) compared with those who had CYP2E1(c1/c2 or c2/c2) genotype and no smoking habit.Conclusion The ploymorphism of CYP2E1 gene was considered as one of the possible susceptible genes and the risk would increase significantly in smokers." @default.
- W2356137283 created "2016-06-24" @default.
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- W2356137283 date "2004-01-01" @default.
- W2356137283 modified "2023-09-25" @default.
- W2356137283 title "Study on the Relationship between Polymorphism of Cytochrome P4502E1 and Susceptibility of Gastric Cardia Cancer" @default.
- W2356137283 hasPublicationYear "2004" @default.
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