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• W2356137425 abstract "Objective To explore anti-inflammatory effects and its mechanisms of water extract of Ageratum conyzoides. L. from Guangxi. Methods 60 mice were randomly divided into five groups: control group,dexamethasone group,water extract of Ageratum conyzoides. L. from Guangxi with high,medium and low dosage group,then induce auricle edema by dimethylbenzene to investigate the anti-inflammatory effect of water extracts of Ageratum conyzoides. L. from Guangxi on auricle edema. Using the same grouping method,induce paw edema by carrageenan to investigate the anti-inflammatory effect of water extracts of Ageratum conyzoides. L. from Guangxi,and measure the content of malondiadehyde( MDA),prostaglandin E2( PGE2) and the activity of superoxide dismutase( SOD) in edema paw. Difference comparison among groups was determined with single factor variance analysis. Comparison between two groups was performed with LSD test. Results Compared with the control group,the water extracts of Ageratum conyzoides. L.from Guangxi with high,medium and low dosage groups could remarkably inhibit the ear edema and the paw edema in mice,the inhibition ratio were 29. 27%,18. 23%,11. 61% and 27. 58%,17. 15%,7. 93% respectively. The difference had statistical significance( P 0. 01). The content of MDA,PGE2and SOD in the edema paw in the control group were 124. 95 ± 15. 71 μg /g,21. 19 ± 3. 27 nmol /ml and162. 19 ± 12. 52 U /ml respectively. The high,medium and low dosage group were( 52. 12 ± 9. 51μg /g,78. 30 ± 11. 60 μg /g and 83. 41 ± 13. 34 μg /g),( 14. 57 ± 2. 51 nmol /ml,15. 40 ± 2. 34 nmol /ml and16. 37 ± 3. 18 nmol /ml) and( 222. 76 ± 19. 59 U /ml,209. 90 ± 15. 30 U /ml and 194. 64 ± 19. 68 U /ml) respectively. Compared with control group,it could remarkably reduce MDA and PGE2production and enhanced activity of SOD in mice inflammatory tissue,the difference had statistical significance( P 0. 01).Conclusion The water extracts of Ageratum conyzoides. L. from Guangxi has significantly anti-inflammatory effects,and its mechanisms may relate to its ability of reducing the content of MDA and PGE2,enhancing the activity of SOD,and scavenging oxygen free radicals in mice inflammatory tissue." @default.
• W2356137425 created "2016-06-24" @default.
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• W2356137425 date "2014-01-01" @default.
• W2356137425 modified "2023-09-25" @default.
• W2356137425 title "Study on anti-inflammatory effects and its mechanisms of water extract of Ageratum conyzoides L.from Guangxi" @default.
• W2356137425 hasPublicationYear "2014" @default.
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